Centers around the lives and loves of 5 young surgical interns at Seattle Grace Hospital. Placed in the most competitive and grueling internship a hospital has, these young interns learn how to become surgeons from some of the best in the business. Derek's previously unknown wife, Addison shows up and tries to win back her busband. Confronted with the two women he loves, Derek is forced to choose between them, a choice that will have wide reaching...

Centered on the personal and professional lives of five surgical interns and their supervisors. Love, lies, and family ties are revealed as the surgeons of Seattle Grace discover that their choices have major unintended consequences.

Expect more competition, more doctors, and much more drama as Seattle Grace merges with a competing hospital. Meredith, Derek, Izzie, and the rest of your favorite characters face a brand new challenge. Battle lines are drawn and rivalries reach new heights in an unforgettable year at Seattle Grace.